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PARLINFO

 

The Hon. Jon Gerrard, P.C.

Date of Birth (yyyy-mm-dd):  1947-10-13

Place of Birth:  Birmingham, England

Profession | Occupation:  professor, scientist, pediatric hematologist, physician, surgeon

Federal Political Experience

Years of Service: 1,316 days (3 years, 7 months, 7 days)

House of Commons

Constituency Political Affiliation at Election Date of Election Result
Selkirk--Interlake Liberal Party of Canada 1997-06-02 Defeated
Portage--Interlake Liberal Party of Canada 1993-10-25 Elected

Parliamentary Group

Party Term
Liberal Party of Canada 1993-10-25 - 1997-06-01

Offices and Roles as a Parliamentarian

Minister of State / Secretary of State
Portfolio Term
Secretary of State (Science, Research and Development)(Western Economic Diversification) 1996-01-25 - 1997-06-10
Secretary of State (Science, Research and Development) 1995-03-29 - 1996-01-24
Secretary of State (Science, Research and Development) 1993-11-04 - 1995-03-28

Provincial / Territorial Political Experience

Provincial / Territorial Political Affiliation
Political Affiliation Province / Territory Term (yyyy-mm-dd)
Liberal Party Manitoba 1998-10-17 -  
Provincial / Territorial Constituency
Constituencies Province / Territory Term (yyyy-mm-dd)
River Heights Legislative Assembly of Manitoba 1999-09-21 -  
Provincial / Territorial Assembly
Assembly Province / Territory Term (yyyy-mm-dd)
Legislative Assembly of Manitoba Manitoba 1999-09-21 -  
Provincial / Territorial Responsibilities
Responsibility Province / Territory Term (yyyy-mm-dd)
Leader of the Liberal Party (Provincial) Manitoba 1998-10-18 -  

Selected Publications

The following is a select bibliography, representing key titles or contributions from the parliamentarian’s collection of published works. To learn more about this parliamentarian’s written works please consult a library near you.

Every effort has been made to ensure the accuracy of the following information. Should you find any errors please contact us via e-mail at: parlinfo@parl.gc.ca.

Platelet aggregation independent of ADP release or prostaglandin synthesis in patients with hermansky-Pudlak syndrome. Prostaglandins and medicine. 6(4):459-72 Apr. 1981

The influence of albumin and calcium on human platelet arachidonic acid metabolism. Blood. 55(3):418-23 Mar. 1980

Activation of permeabilized platelets by inositol-1,4,5-trisphosphate. Thrombosis research. 40(4):499-509 Nov. 15, 1985

Correlation of the antiproliferative action of diphenylmethane-derivative antiestrogen binding site ligands with antagonism of histamine binding but not of protein kinase C-mediated phosphorylation. Cancer Research. 48(14):3954-8 July 15, 1988

Effect of low dose prostacyclin infusion on blood flow in acutely ischemic canine myocardium. Prostaglandins and Medicine. 5(3):209-19 Sept. 1980

Comparison of arachidonic acid metabolism in nasal polyps and eosinophils. International archives of allergy and applied immunology. 82(1):83-8 1987

The protein CD63 is in platelet dense granules, is deficient in a patient with Hermansky-Pudlak syndrome, and appears identical to granulophysin. Journal of Clinical Investigation. 91(4):1775-82 Apr. 1993

Blood pressure during pregnancy in Canadian Inuit: community differences related to diet. Canadian Medical Association Journal. 145(5): 445-54 Sept. 1, 1991

Reciprocal transmembranous receptor-cytoskeleton interactions in concanavalin A-activated platelets. Journal of cell biology. 101(3): 993-1000 Sept. 1985

The influence of prostaglandin endoperoxides on platelet ultrastructure. American Journal of Pathology. 80(2):189-201 Aug. 1975

Lysophosphatidic acids. Influence on platelet aggregation and intracellular calcium flux. American Journal of Pathology. 96(2):423-38 Aug. 1979

Medical research in Canada: the fascinating stories of 30 Canadian scientists / edited by Jon M.Gerrard. Headingley, Man.: White Horse Publishers; viii, 152 p. 1985

A study of the role of prostaglandins and thromboxanes in platelet activation. [Minneapolis ]: Thesis--University of Minnesota; ix, ii-iv, 244 leaves 1978

Platelet dense granule membranes contain both granulophysin and P-selectin (GMP-140). Blood. 80(1):143-52 July 1992

Phospholipase C activity in platelets from Bernard-Soulier syndrome patients. Arteriosclerosis and thrombosis. 13(11):1567-71 Nov. 1993

Charles Broley: an extraordinary naturalist. Headingley, Man: White Horse Plains Publishers; ii, 59 p c1983

1-Arachidonyl-monoglyceride causes platelet aggregation--implications for an acylglycerol acylhydrolase involvement in control of prostaglandin synthesis. Progress in lipid research. 20: 575-8 1981

The influence of prostaglandin G2 on platelet ultrastructure and platelet secretion. American Journal of Pathology. 86(1):99-115 Jan. 1977

Glycation of platelet protein in diabetes mellitus: lack of correlation with platelet function. Clinical biochemistry. 20(5):359-63 Oct. 1987

Rural health care. Canadian Medical Association Journal. 149:531-2 Sept. 1993

Type A behavior and alcohol consumption: effects on resting and post-exercise bleeding time thromboxane and prostacyclin metabolites. Prostaglandins, leukotrienes, and essential fatty acids. 48(2):143-8 Feb. 1993

Studies of the mechanism of natural killer (NK) degranulation and cytotoxicity. Journal of leukocyte biology. 47(1):39-48 Jan. 1990

The effect of exercise on bleeding time and local production of prostacyclin and thromboxane. European journal of applied physiology and occupational physiology. 59(5):355-9 1989

A role for intracellular histamine in collagen-induced platelet aggregation. Blood. 75(2):407-14 Jan.15, 1990

Effect of prostaglandin on the composition of chinchilla middle ear effusion. Annals of otology, rhinology & laryngology. Supplement. 89(3 Pt 2):153-60 May-June 1980

Selective deficiency in collagen-induced platelet aggregation during L-asparaginase therapy. American journal of pediatric hematology/oncology. 2(3):207-12 Fall 1980

Identification of the molecular species of lysophosphatidic acid produced when platelets are stimulated by thrombin. Biochimica et biophysica acta. 1001(3):282-5 Feb. 1989

Birds of the Besnard Lake area: North-Central Saskatchewan 1968-1994. Regina: Saskatchewan Natural History Society; 97 p. 1996

Are lysophosphatidic acids or phosphatidic acids involved in stimulus activation coupling in platelets?. Blood. 60(3):642-9 Sept. 1982

Disulfide-linked and transglutaminase-catalyzed protein assemblies in platelets. Blood. 66(1):143-51 July 1985

The influence of metabolities on the assay of platelet serotonin. Thrombosis Research. 10(6):791-802 June 1977

Arachidonic acid deficiency in streptozotocin-induced diabetes. Proceedings of the National Academy of Sciences of the United States of America. 80(8):2375-9 Apr. 1983

Essential fatty acid status of neonates born to Inuit mothers: comparison with Caucasian neonates and effect of diet. Prostaglandins, leukotrienes, and essential fatty acids. 45 : 125-30 Feb. 1992

Alpha tocopherol quinone (alpha TQ): a potent inhibitor of platelet function. Progress in lipid research. 20:549-52 1981

A role for protein kinase C in the membrane fusion necessary for platelet granule secretion. Blood. 74(7):2405-13 Nov. 1989

The effects of 1-oleoyl-2-acetylglycerol on platelet protein phosphorylation and platelet ultrastructure. American Journal of Pathology. 121(1):79-87 Oct. 1985

Vanadate activates platelets by enhancing arachidonic acid release. Blood. 81(9):2329-38 May 1993

Labile aggregation stimulating substance (LASS): the factor from storage pool deficient platelets correcting defective aggregation and release of aspirin treated normal platelets. British Journal of Haematology. 29(4):657-65 Apr. 1975

Interactions of zinc and arachidonic acid. Prostaglandins and Medicine. 6(1):91-9 Jan. 1981

Clot retraction facilitates clot lysis. Blood. 57(1):44-8 Jan. 1981

Rapid ultrastructural changes in the dense tubular system following platelet activation. Blood. 80()3):718-23 Aug. 1992

The empty sack syndrome: a platelet storage pool deficiency associated with empty dense granules. British Journal of Haematology. 86(3):574-82 Mar. 1994

Prostaglandins in experimental otitis media. Archives of Otorhinolaryngology. 225(3):207-9 1979

Epinephrine reduction of heme: implication for understanding the transmission of an agonist stimulus. Science. 215(4528):71-3 Jan. 1982

A role for intracellular histamine in ultrastructural changes induced in platelets by phorbol esters. Arteriosclerosis. 9(5):684-9 Sept.-Oct. 1989

The involvement of prostaglandin endoperoxide formation in the elevation of cyclic GMP levels during platelet aggregation. Journal of cyclic nucleotide research. 3(1):37-44 Feb. 1977

The influence of amines on various platelet responses. Biochimica et biophysica acta. 734(2):267-73 Oct. 12, 1983

Vitamin E and platelets: cooperative interactions with nitroblue tetrazolium on inhibition of adhesion, aggregation and secretion. American journal of pediatric hematology/oncology. 1(2):155-68 Summer 1979

Structure of the active site of prostaglandin synthase from studies of depsides: an alternate view. Prostaglandins, leukotrienes, and medicine. 13(2):139-42 Feb. 1984

Shortening of bleeding time by 1-deamino-8-D-arginine vasopressin in various bleeding disorders. Lancet. 1(8387):1145-89 May 26, 1984

The importance of international cooperation in science and technology. SRA Journal. 28(1/2):29(4 pgs) Summer/Fall 1996

Comparison of the effect of canola oil and sunflower oil on plasma lipids and lipoproteins and on in vivo thromboxane A2 and prostacyclin production in healthy young men. American Journal of Clinical Nutrition. 50(6):1382-8 Dec. 1989

Platelet protein phosphorylation. Advances in experimental medicine and biology. 192:235-48 1985

A hypothesis for a role for unsaturated fatty acids in electron transport and its potential application to understanding the mitochondrial respiratory chain. Medical Hypotheses. 6(5):491-9 May 1980

Fibrinogen is the receptor for the endogenous lectin of human platelets. Nature. 289(5799):688-90 Feb. 19, 1981

Platelet storage pool deficiency and prostaglandin synthesis in chronic granulocytic leukaemia. British Journal of Haematology. 40(4):597-607 Dec. 1978

Phosphatidic acid releases calcium from a platelet membrane fraction in vitro. Prostaglandins and Medicine. 1(5):387-96 Nov. 1978

Separable assembly of platelet pseudopodal and contractile cytoskeletons. Cell. 30(2):385-93 Sept. 1982

The chemiluminescence response of human platelets. Journal of Clinical Investigation. 61(3):807-14 Mar. 1978

Inhibition of platelet lipoxygenase by toluene-3,4-dithiol and other ferric iron chelators. Prostaglandins, leukotrienes, and medicine. 10(1):107-8 Jan. 1983

Biochemical studies of two patients with the gray platelet syndrome. Selective deficiency of platelet alpha granules. Journal of Clinical Investigation. 66(1):102-9 July 1980

Role of materials in an innovative economy. CIM Bulletin. Montreal: 88(995):92 Nov./Dec. 1995

Lysophosphatidic acid can activate platelets without increasing 32P-labelling of phosphatidic acid. Biochimica et biophysica acta.. 795(3):487-92 Oct. 4, 1984

Possible mechanisms of epinephrine actions in quin-2-loaded platelets refractory to arachidonic acid. Biochemical medicine and metabolic biology. 50(3):322-37 Dec. 1993

Phospholipid metabolism and cell stimulus activation coupling in platelets and other blood cells. Survey and synthesis of pathology research. 3(6):457-76 1984

Histamine as an intracellular messenger in human platelets. Advances in experimental medicine and biology. 344:209-19 1993

The bald eagle in Canada : proceedings of Bald Eagle Days, Winnipeg, August 18-20, 1983 / Jon M. Gerrard and Terrence M. Ingram, editors. Headingley, Man: White Horse Plains Publishers; vii, 272 p. c1985

Platelet storage pool deficiency, leukemia, and myelodysplastic syndromes. Leukemia & lymphoma. 8(4-5):277-81 Nov. 1992

Response of human bone marrow progenitor cells to X-rays in vitro. International journal of radiation biology. 54(4):593-600 Oct. 1988

Ultrastructural features of abnormal blood platelets. A review. American Journal of Pathology. 83(3):589-632 June 1976

Reduction of ferric heme to ferrous by lipid peroxides: possible relevance to the role of peroxide tone in the regulation of prostaglandin synthesis. Prostaglandins and Medicine. 4(2):73-8 Feb. 1980

Bleeding/bruising symptomatology in children with and without bleeding disorders. Thrombosis and Haemostasis. 65(3):237-41 Mar. 1991

Platelet-leukocyte interactions following arterial endothelial injury. American Journal of Pathology. 96(2):567-80 Aug. 1979

Alteration in the balance of prostaglandin and thromboxane synthesis in diabetic rats. Journal of Laboratory and Clinical Medicine. 95(6):950-8 June 1980

Prostaglandins as reducing agents: a model of adenylate cyclase activation?. Prostaglandins. 36(5):667-71 Nov. 1988

Platelet storage pool deficiency: diagnosis in patients with prolonged bleeding times and normal platelet aggregation. British Journal of Haematology. 75(1):118-21 May 1990

Effect of dietary alpha-linolenic acid and its ratio to linoleic acid on platelet and plasma fatty acids and thrombogenesis. Lipids. 28(9):811-7 Sept. 1993

Prostaglandin endoperoxides promote calcium release from a platelet membrane fraction in vitro. Prostaglandins and Medicine. 1(15):373-85 Nov. 1978

The role of iron in prostaglandin synthesis: ferrous iron mediated oxidation of arachidonic acid. Prostaglandins and Medicine. 1(1):55-70 July 1978

Long-term cultures of human peripheral blood lymphocytes with recombinant human interleukin-2 generate a population of virtually pure CD3+ CD16- CD56- large granular lymphocyte LAK cells. Clinical and experimental immunology. 82(2):416-21 Nov. 1990

Effects of nitroblue tetrazolium and vitamin E on platelet ultrastructure, aggregation, and secretion. American Journal of Pathology. 88(2):387-402 Aug. 1977

The platelet dense tubular system: its relationship to prostaglandin synthesis and calcium flux. Thrombosis and Haemostasis. 40(2):224-31 Oct. 31, 1978

Prostaglandins and leukotrienes: blood and vascular cell function. New York: M. Dekker; xii, 320 p. c1985

L-asparaginase-induced hypocomplementemia in acute lymphocytic leukemia (ALL) of childhood. American journal of pediatric hematology/oncology. 1(1):5-7 Spring 1979

Estimating closed population size and number of marked animals from sighting data. 55(4):716(15 pgs) Oct. 1991

Ultrastructure of clots during isometric contraction. Journal of Cell Biology. 93(3):775-87 June 1982

Histamine formed in stimulated human platelets is cytoplasmic. Biochemical and biophysical research communications. 164(1):164-8 Oct. 16, 1989

Inhibition of intravascular platelet aggregation by endothelium-derived relaxing factor: reversal by red blood cells. Blood. 76(5):953-8 Sept.1, 1990

Oral contraceptive use alters the balance of platelet prostaglandin and thromboxane synthesis. Prostaglandins and Medicine. 1(1):5-11 July 1978

Evidence that the peroxidase of the fatty acid cyclooxygenase acts via a Fenton type of reaction. Prostaglandins, leukotrienes, and medicine. 12(1):73-6 Sept. 1983

Activation of inositol cycle in large granular lymphocyte leukemia RNK following contact with an NK-sensitive tumor. Advances in prostaglandin, thromboxane, and leukotriene research. 17A:573-6 1987

Cyclic AMP and platelet prostaglandin synthesis. Prostaglandins. 14(1):39-50 July 1977

Vitamin E inhibits the release of calcium from a platelet fraction in vitro. Prostaglandins and Medicine. 2(3):203-16 Mar. 1979

Epinephrine and other activators of prostaglandin endoperoxide synthetase can reduce Fe3+-heme to Fe2+-heme. Prostaglandins and Medicine. 5(5):357-64 Nov. 1980

Battling for a better Manitoba: a history of the provincial Liberal Party. Winnipeg: Heartland Associates; 208 p. 2006

Plasminogen, plasminogen activator, and platelets in the regulation of clot lysis. Reconstitution and patient studies. Journal of laboratory and clinical Medicine. 100(6):986-96 Dec. 1982

Ferrous iron mediated oxidation of arachidonic acid: studies employing nitroblue tetrazolium (NBT). Prostaglandins and Medicine. 1 : 304-17 Oct. 1978

Inhibition of ferrous iron induced oxidation of arachidonic acid by indomethacin. Prostaglandins and Medicine. 2(2):97-108 Feb. 1979

Biology and management of bald eagles and ospreys : proceedings of 1st International Symposium on Bald Eagles and Ospreys, Montréal, 28-29 October, 1981 / David M. Bird, chief editor, Norman R. Seymour, Jon M. Gerrard, assistant editors. [Ste. Anne de Bellevue, Québec]: Macdonald Raptor Research Centre of McGill University : Raptor Research Foundation; x, 325 p. 1983

Labile aggregation stimulating substance, free fatty acids, and platelet aggregation. Journal of Laboratory and Clinical Medicine. 87(1):73-82 Jan. 1976

Proceedings: Effects of pH on arachidonic acid induced platelet aggregation. Thrombosis et diathesis haemorrhagica. 34(2):560 Nov. 15, 1975

Prostaglandins and otitis media: studies in the chinchilla. Otolaryngology and head and neck surgery. 88(3):316-23 May/June 1980

The influence of reserpine and ethylenediaminetetraacetic acid (EDTA) on serotonin storage organelles of blood platelets. American Journal of Pathology. 87(3):633-46 June 1977

Stimulation of platelet protein phosphorylation by arachidonic acid and endoperoxide analogs. Prostaglandins. 22(1):81-94 July 1981

Prostaglandins and thromboxanes: 'middlemen' modulating platelet function in hemostasis and thrombosis. Progress in hemostasis and thrombosis. 4:87-125 1978

Histamine is an intracellular messenger mediating platelet aggregation. Science. 243(4898):1596-9 Mar. 1989

Synthesis of intracellular histamine in platelets is associated with activation of protein kinase C, but not with mobilization of Ca2+. Biochemical journal. 273(Pt 2): 405-8 Jan. 15, 1991

Localization of platelet prostaglandin production in the platelet dense tubular system. American Journal of Pathology. 83(2):283-98 May 1976

Platelet aggregation and the influence of prostaglandins. Methods in enzymology. 86:642-54 1982

Differential effects of spermine on aggregation, inositol phosphate formation and protein phosphorylation in human platelets in response to thrombin, arachidonic acid and lysophosphatidic acid. Biochimica et biophysica acta. 883(2):247-52 Sept. 4, 1986

Interaction of arachidonic acid and heme iron in the synthesis of prostaglandins. Advances in prostaglandin and thromboxane research. 6:157-61 1980

Inherited platelet-storage pool deficiency associated with a high incidence of acute myeloid leukaemia. British journal of haematology. 79(2):246-55 Oct. 1991

Effects of the lonophore A23187 on blood platelets I. Influence on aggregation and secretion. American Journal of Pathology. 77(2):135-49 Nov. 1974

Granulophysin is located in the membrane of azurophilic granules in human neutrophils and mobilizes to the plasma membrane following cell stimulation. American Journal of Pathology. 144(6):1369-80 June 1994

Oncornavirus-like particles from cultured bone marrow cells preceding leukemia and malignant histiocytosis. Proceedings of the National Academy of Sciences of the United States of America. 72(7):2804-8 July 1975

A hypothesis for the mechanism of superoxide production by phagocytic cells. Medical Hypotheses. 7(11):1389-95 Nov. 1981

Fibroblasts require protein kinase C activation to respond to hyaluronan with increased locomotion. Matrix biology. 20(3):183-92 June 2001

The ultrastructure of defective human platelets. Molecular and cellular biochemistry. 21(2):109-28 Nov. 1, 1978

The interactive effects of Type A behavior and hostility on bleeding time thromboxane and prostacyclin formation. Journal of psychosomatic research. 35(6):645-50 1991

Inhibition of prostaglandin (PG) synthesis in sheep vesicular gland microsomes (SVGM) by nitroblue tetrazolium (NBT) and vitamin E (VE). Prostaglandins and Medicine. 2(2):111-21 Feb. 1979

alpha-Actinin deficiency in thrombasthenia: possible identity of alpha-actinin and glycoprotein III. American Journal of Pathology. 94(3):509-28 Mar. 1979

Smoking and platelet labile aggregation stimulating substance (LASS) synthesizing activity. Thrombosis Research. 9(6):661-8 Dec. 1976

Evidence for two mechanisms of thrombin-induced platelet activation: one proteolytic, one receptor mediated. Biochemistry and cell biology. 67(7):332-6 July 1989

Measurements of 6-keto-prostaglandin F1 alpha and thromboxane B2 in bleeding time blood: relation to bleeding and vascular disorders?. Canadian journal of physiology and pharmacology. 67(8):922-8 Aug. 1989

Proceedings: Differences in platelet storage pool deficiency (SPD) of Hermansky Pudlak syndrome (HPS) and non-albinos (NA). Thrombosis et diathesis haemorrhagica. 34(1):360-1 Sept.30, 1975

Biphasic modulation of platelet phospholipase A2 activity and platelet aggregation by mepacrine (quinacrine). Biochimica et biophysica acta. 713(1):170-2 Oct. 14, 1982

Platelet ultrastructure in relation to platelet function. Progress in clinical and biological research. 28:5-23 1978

The influence of vitamin E quinone on platelet structure, function, and biochemistry. Blood. 55(6):907-14 June 1980

Interaction of microtubules and microfilaments in platelet contractile physiology. Methods and achievements in experimental pathology. 9 : 1-39 1979

Histamine as an intracellular messenger. Biochemical pharmacology. 40(8):1677-81 Oct. 1990

The role of phosphorylation/dephosphorylation reactions in the function of blood platelets. Agents and actions. Supplements. 20:129-45 1986

Protein kinase C, membrane fusion and platelet granule secretion. Biochemical Society transactions. 21(2):289-93 May 1993

Increased phosphatidic acid and decreased lysophosphatidic acid in response to thrombin is associated with inhibition of platelet aggregation. Biochemistry and cell biology. 71(9-10):432-9 Sept./Oct. 1993

Effect of cholesterol on production of thromboxane b2 by platelets in vitro. New England Journal of Medicine. 302(1):6-10 Jan. 3, 1980

Lysophosphatidic acids. II. Interaction of the effects of adenosine diphosphate and lysophosphatidic acids in dog, rabbit, and human platelets. American Journal of Pathology. 97(3):531-47 Dec. 1979

Salicylic acid inhibition of the irreversible effect of acetylsalicyclic aicd on prostaglandin synthetase may be due to competition for the enzyme cationic binding site. Prostaglandins and Medicine. 6(2):161-4 Feb. 1981

The endogenous lectin of human platelets is an alpha-granule component. Blood. 58(1):153-7 July 1981

Free radicals in health and disease. Molecular and cellular biochemistry. 84(2):121-2 Dec. 1988

The structured interview elicits a differential prostacyclin response in A and B behaviour types. Canadian Journal of Cardiology. 7(4):170-4 May 1991

Synthesis and biological evaluation of 9,11-azo-13-oxa-15-hydroxyprostanoic acid, a potent inhibitor of platelet aggregation. Journal of medicinal chemistry. 22(11):1402-8 Nov. 1979

Effects of the lonophore A23187 on the blood platelets II. Influence on ultrastructure. American Journal of Pathology. 77(2):151-66 Nov. 1974

Wide distribution of granulophysin epitopes in granules of human tissues. Laboratory investigation. 68(5):509-19 May 1993

A hypothesis for the interaction of heme and arachidonic acid in the synthesis of prostaglandins. Medical Hypotheses. 5(6):683-93 June 1979

1-arachidonyl-monoglyceride causes platelet aggregation: indirect evidence for an acylglycerol acylhydrolase involvement in the release of arachidonic acid for prostaglandin synthesis. Prostaglandins and Medicine. 4(6):419-30 June 1980

Long-term science and technology policy key to sustainable economic growth. Canadian Chemical News. 46(8):26 Sept. 1994

Mepacrine (quinacrine) inhibition of thrombin-induced platelet responses can be overcome by lysophosphatidic acid. Biochimica et biophysica acta. 842(2-3):189-94 Oct. 17, 1985

Fatty acid composition of umbilical arteries and veins: possible implications for the fetal EFA-status. Lipids. 24(6):511-7 June 1989

Lysophosphatidic acids: III. Enhancement of neutrophil chemotaxis. American journal of pathology. 100(3):609-18 Sept. 1980

Identification of prostaglandins and other arachidonic acid metabolites in experimental otitis media. Prostaglandins, leukotrienes, and medicine. 8(3):249-61 Mar. 1982

An immunoenzyme histochemical technique for the detection of platelet antibodies from the serum of patients with idiopathic (autoimmune) thrombocytopenic purpura (ITP). British Journal of Haematology. 37(2):265-75 Oct. 1977

Growth-promoting activity of desmopressin in murine leukemia cells treated in vitro. Cancer Research. 48(24 Pt 1):7055-9 Dec. 1988

Arachidonic acid metabolism in nasal polyps and allergic inflammation. Minnesota medicine. 64(10):605-10 Oct. 1981

Hyperactivity of neutrophil leukotactic responses during active bacterial infection. Journal of Clinical Investigation. 53(4):996-1002 Apr. 1974

A reassessment of the bleeding time: association of age, hematocrit, platelet function, von Willebrand factor, and bleeding time thromboxane B2 with the length of the bleeding time. Clinical and investigative medicine. 12(3):165-71 June 1989

Arachidonic acid peroxidation, prostaglandin synthesis and platelet function. Photochemistry and photobiology. 28(4-5):845-50 Oct./Nov. 1978

Recent advances in platelet structural physiology. Supplementum... ad Thrombosis and haemostasis. 63:49-60 1978

The influence of aspirin and indomethacin on the platelet contractile wave. American Journal of Pathology. 82(3):513-26 Mar. 1976

Factors influencing bald eagle densities in North Central Saskatchewan. Journal of Wildlife Management. 57(4):771 (8 pgs) Oct. 1993

Production of inositol-phospholipid-derived second messengers in a rat natural killer cell line exposed to susceptible tumor targets. Natural immunity and cell growth regulation. 8(4):223-30 1989

Identification of a platelet dense granule membrane protein that is deficient in a patient with the Hermansky-Pudlak syndrome. Blood. 77(1):101-12 Jan.1, 1991

Post-receptor events associated with thrombin-induced platelet activation. Blood coagulation & fibrinolysis. 4(6):975-91 Dec. 1993

Contractile activity of neonatal platelets. Pediatric research. 21(3):293-5 Mar. 1987

Characterization of the gastroprotective effects of N,N-diethyl-2-[4-(phenylmethyl)phenoxy]-ethanamine hydrochloride, a non-H1/non-H2 histamine antagonist. Digestion. 47(3):143-8 1990

Reduction of a disulfide bond by beta-adrenergic agonists: evidence in support of a general. Medical Hypotheses. 22(1):45-9 Jan. 1987

A role for prostacyclin in bruising symptomatology. Pediatrics. 90(1 Pt 1):33-6 July 1992

Enhanced electron transfer by GTP: cross-membrane electron signaling by G-proteins?. Free radical biology & medicine. 11(2):187-90 1991

Reduction of a metal or disulfide bond associated with the receptor: a general hypothesis for the mechanism of action of adrenergic agents. Medical Hypotheses. 22(1):35-44 Jan. 1987

Evaluation of the careers of graduates of the University of Manitoba's BSc (Medicine) program. Canadian Medical Association Journal. 139(11):1063-8 Dec. 1, 1988

Platelets from bleeding Simmental cattle mobilize calcium, phosphorylate myosin light chain and bind normal numbers of fibrinogen molecules but have abnormal cytoskeletal assembly and aggregation in response to ADP. Thrombosis and haemostasis. 71(2):240-6 Feb. 1994

Phosphorylation of platelet actin-binding protein during platelet activation. Blood. 59(3):466-71 Mar. 1982

The effect of regular and enteric-coated aspirin on bleeding time, thromboxane, and prostacyclin. Prostaglandins, leukotrienes, and essential fatty acids. 49(1):515-20 July 1993

The inhibition of platelet aggregation of metastatic H-ras-transformed 10T1/2 fibroblasts with castanospermine, an N-linked glycoprotein processing inhibitor. Cancer letters. 60(3):185-91 Dec.1, 1991

Child health research in Manitoba. Headingley, Man.: White Horse Plains Publishers; viii, 120 p. 1993

The young investigator in Canada. Clinical and investigative medicine. 15(3):255-6 June 1992

Studies in patients with bleeding disorders show that platelet-vessel interaction is important for thromboxane formation in bleeding time wounds. Thrombosis research. 60(1):79-85 Oct. 1990

Effects of 2,2'-dipyridyl and related compounds on platelet prostaglandin synthesis and platelet function. Biochimica et biophysica acta. 628(4):468-79 Apr. 3, 1980

Allopurinol can act as an electron transfer agent. Is this relevant during reperfusion injury?. Biochemical and biophysical research communications. 137(1):76-9 May 29, 1986

The bald eagle: haunts and habits of a wilderness monarch. Washington: Smithsonian Institution Press; xiv, 177 p. 1988

Halothane stimulates the aggregation of platelets of both normal individuals and those susceptible to malignant hyperthermia. British Journal of Anaesthesia. 55(12):1249-57 Dec. 1983

Sharing of antigenic epitopes between synaptophysin and granulophysin. Journal of cellular biochemistry. 49(1):59-65 May 1992

The influence of lysophosphatidic acid on platelet protein phosphorylation. Biochemistry and cell biology. 65(7):642-50 July 1987

An enzyme-linked immunosorbent assay for 6-keto PGF1 alpha. Prostaglandins. 31(3):375-83 Mar. 1986

A penicillin-resistant pneumococcus. Journal of pediatrics. 93(4):624-6 Oct. 1978

Platelet aggregation: cellular regulation and physiologic role. Hospital practice (Office ed.). 23 (1):89-98ff. Jan. 15, 1988

Reduction of heme by lipid peroxides and its potential relevance to understanding control of cyclo-oxygenase activity. Progress in lipid research.. 20:299-301 1981

Evaluation of the careers of graduates of the University of Manitoba's BSc (Medicine) program. Canadian Medical Association Journal. 139:1063-68 Dec. 1, 1988

The structure and function of platelets, with emphasis on their contractile nature. Pathobiology annual. 6:31-59 1976

Biochemical and ultrastructural studies suggest that the effects of thapsigargin on human platelets are mediated by changes in intracellular calcium but not by intracellular histamine. Thrombosis and haemostasis. 68(6):714-8 Dec. 7, 1992

Plasma phospholipid fatty acids in the Central Canadian arctic: biocultural explanations for ethnic differences. American journal of physical anthropology. 109(1):9-18 May 1999

Protein phosphorylation and platelet secretion. Nouvelle revue francaise d'hematologie. 27(4):267-73 1985

Leukophysin: a 28-kDa granule membrane protein of leukocytes. Journal of Immunology. 147(9):3053-9 Nov.1, 1991

Phosphorylation of tyrosine enhances its electron transfer capability: a model of redox modulation as oncogene expression?. Medical Hypotheses. 26(4):271-3 Aug. 1988

In vivo measurement of thromboxane B2 and 6-keto-prostaglandin F1 alpha in humans in response to a standardized vascular injury and the influence of aspirin. Circulation. 79(1):29-38 Jan. 1989

Wiskott-Aldrich syndrome: detection of carrier state by metabolic stress of platelets. Lancet. 1(8056):121-3 Jan. 21, 1978

Aerobic fitness level (VO2max) moderates the increased cardiovascular function and basal thromboxane formation of young healthy Type A males. Behavioral medicine. 18(1):33-9 Spring 1992

Federal Political Experience

Years of Service: 1,316 days (3 years, 7 months, 7 days)

House of Commons

Constituency Political Affiliation at Election Date of Election Result
Selkirk--Interlake Liberal Party of Canada 1997-06-02 Defeated
Portage--Interlake Liberal Party of Canada 1993-10-25 Elected

Parliamentary Group

Party Term
Liberal Party of Canada 1993-10-25 - 1997-06-01

Offices and Roles as a Parliamentarian

Minister of State / Secretary of State
Portfolio Term
Secretary of State (Science, Research and Development)(Western Economic Diversification) 1996-01-25 - 1997-06-10
Secretary of State (Science, Research and Development) 1995-03-29 - 1996-01-24
Secretary of State (Science, Research and Development) 1993-11-04 - 1995-03-28

Provincial / Territorial Political Experience

Provincial / Territorial Political Affiliation
Political Affiliation Province / Territory Term (yyyy-mm-dd)
Liberal Party Manitoba 1998-10-17 -  
Provincial / Territorial Constituency
Constituencies Province / Territory Term (yyyy-mm-dd)
River Heights Legislative Assembly of Manitoba 1999-09-21 -  
Provincial / Territorial Assembly
Assembly Province / Territory Term (yyyy-mm-dd)
Legislative Assembly of Manitoba Manitoba 1999-09-21 -  
Provincial / Territorial Responsibilities
Responsibility Province / Territory Term (yyyy-mm-dd)
Leader of the Liberal Party (Provincial) Manitoba 1998-10-18 -  

Selected Publications

The following is a select bibliography, representing key titles or contributions from the parliamentarian’s collection of published works. To learn more about this parliamentarian’s written works please consult a library near you.

Every effort has been made to ensure the accuracy of the following information. Should you find any errors please contact us via e-mail at: parlinfo@parl.gc.ca.

Platelet aggregation independent of ADP release or prostaglandin synthesis in patients with hermansky-Pudlak syndrome. Prostaglandins and medicine. 6(4):459-72 Apr. 1981

The influence of albumin and calcium on human platelet arachidonic acid metabolism. Blood. 55(3):418-23 Mar. 1980

Activation of permeabilized platelets by inositol-1,4,5-trisphosphate. Thrombosis research. 40(4):499-509 Nov. 15, 1985

Correlation of the antiproliferative action of diphenylmethane-derivative antiestrogen binding site ligands with antagonism of histamine binding but not of protein kinase C-mediated phosphorylation. Cancer Research. 48(14):3954-8 July 15, 1988

Effect of low dose prostacyclin infusion on blood flow in acutely ischemic canine myocardium. Prostaglandins and Medicine. 5(3):209-19 Sept. 1980

Comparison of arachidonic acid metabolism in nasal polyps and eosinophils. International archives of allergy and applied immunology. 82(1):83-8 1987

The protein CD63 is in platelet dense granules, is deficient in a patient with Hermansky-Pudlak syndrome, and appears identical to granulophysin. Journal of Clinical Investigation. 91(4):1775-82 Apr. 1993

Blood pressure during pregnancy in Canadian Inuit: community differences related to diet. Canadian Medical Association Journal. 145(5): 445-54 Sept. 1, 1991

Reciprocal transmembranous receptor-cytoskeleton interactions in concanavalin A-activated platelets. Journal of cell biology. 101(3): 993-1000 Sept. 1985

The influence of prostaglandin endoperoxides on platelet ultrastructure. American Journal of Pathology. 80(2):189-201 Aug. 1975

Lysophosphatidic acids. Influence on platelet aggregation and intracellular calcium flux. American Journal of Pathology. 96(2):423-38 Aug. 1979

Medical research in Canada: the fascinating stories of 30 Canadian scientists / edited by Jon M.Gerrard. Headingley, Man.: White Horse Publishers; viii, 152 p. 1985

A study of the role of prostaglandins and thromboxanes in platelet activation. [Minneapolis ]: Thesis--University of Minnesota; ix, ii-iv, 244 leaves 1978

Platelet dense granule membranes contain both granulophysin and P-selectin (GMP-140). Blood. 80(1):143-52 July 1992

Phospholipase C activity in platelets from Bernard-Soulier syndrome patients. Arteriosclerosis and thrombosis. 13(11):1567-71 Nov. 1993

Charles Broley: an extraordinary naturalist. Headingley, Man: White Horse Plains Publishers; ii, 59 p c1983

1-Arachidonyl-monoglyceride causes platelet aggregation--implications for an acylglycerol acylhydrolase involvement in control of prostaglandin synthesis. Progress in lipid research. 20: 575-8 1981

The influence of prostaglandin G2 on platelet ultrastructure and platelet secretion. American Journal of Pathology. 86(1):99-115 Jan. 1977

Glycation of platelet protein in diabetes mellitus: lack of correlation with platelet function. Clinical biochemistry. 20(5):359-63 Oct. 1987

Rural health care. Canadian Medical Association Journal. 149:531-2 Sept. 1993

Type A behavior and alcohol consumption: effects on resting and post-exercise bleeding time thromboxane and prostacyclin metabolites. Prostaglandins, leukotrienes, and essential fatty acids. 48(2):143-8 Feb. 1993

Studies of the mechanism of natural killer (NK) degranulation and cytotoxicity. Journal of leukocyte biology. 47(1):39-48 Jan. 1990

The effect of exercise on bleeding time and local production of prostacyclin and thromboxane. European journal of applied physiology and occupational physiology. 59(5):355-9 1989

A role for intracellular histamine in collagen-induced platelet aggregation. Blood. 75(2):407-14 Jan.15, 1990

Effect of prostaglandin on the composition of chinchilla middle ear effusion. Annals of otology, rhinology & laryngology. Supplement. 89(3 Pt 2):153-60 May-June 1980

Selective deficiency in collagen-induced platelet aggregation during L-asparaginase therapy. American journal of pediatric hematology/oncology. 2(3):207-12 Fall 1980

Identification of the molecular species of lysophosphatidic acid produced when platelets are stimulated by thrombin. Biochimica et biophysica acta. 1001(3):282-5 Feb. 1989

Birds of the Besnard Lake area: North-Central Saskatchewan 1968-1994. Regina: Saskatchewan Natural History Society; 97 p. 1996

Are lysophosphatidic acids or phosphatidic acids involved in stimulus activation coupling in platelets?. Blood. 60(3):642-9 Sept. 1982

Disulfide-linked and transglutaminase-catalyzed protein assemblies in platelets. Blood. 66(1):143-51 July 1985

The influence of metabolities on the assay of platelet serotonin. Thrombosis Research. 10(6):791-802 June 1977

Arachidonic acid deficiency in streptozotocin-induced diabetes. Proceedings of the National Academy of Sciences of the United States of America. 80(8):2375-9 Apr. 1983

Essential fatty acid status of neonates born to Inuit mothers: comparison with Caucasian neonates and effect of diet. Prostaglandins, leukotrienes, and essential fatty acids. 45 : 125-30 Feb. 1992

Alpha tocopherol quinone (alpha TQ): a potent inhibitor of platelet function. Progress in lipid research. 20:549-52 1981

A role for protein kinase C in the membrane fusion necessary for platelet granule secretion. Blood. 74(7):2405-13 Nov. 1989

The effects of 1-oleoyl-2-acetylglycerol on platelet protein phosphorylation and platelet ultrastructure. American Journal of Pathology. 121(1):79-87 Oct. 1985

Vanadate activates platelets by enhancing arachidonic acid release. Blood. 81(9):2329-38 May 1993

Labile aggregation stimulating substance (LASS): the factor from storage pool deficient platelets correcting defective aggregation and release of aspirin treated normal platelets. British Journal of Haematology. 29(4):657-65 Apr. 1975

Interactions of zinc and arachidonic acid. Prostaglandins and Medicine. 6(1):91-9 Jan. 1981

Clot retraction facilitates clot lysis. Blood. 57(1):44-8 Jan. 1981

Rapid ultrastructural changes in the dense tubular system following platelet activation. Blood. 80()3):718-23 Aug. 1992

The empty sack syndrome: a platelet storage pool deficiency associated with empty dense granules. British Journal of Haematology. 86(3):574-82 Mar. 1994

Prostaglandins in experimental otitis media. Archives of Otorhinolaryngology. 225(3):207-9 1979

Epinephrine reduction of heme: implication for understanding the transmission of an agonist stimulus. Science. 215(4528):71-3 Jan. 1982

A role for intracellular histamine in ultrastructural changes induced in platelets by phorbol esters. Arteriosclerosis. 9(5):684-9 Sept.-Oct. 1989

The involvement of prostaglandin endoperoxide formation in the elevation of cyclic GMP levels during platelet aggregation. Journal of cyclic nucleotide research. 3(1):37-44 Feb. 1977

The influence of amines on various platelet responses. Biochimica et biophysica acta. 734(2):267-73 Oct. 12, 1983

Vitamin E and platelets: cooperative interactions with nitroblue tetrazolium on inhibition of adhesion, aggregation and secretion. American journal of pediatric hematology/oncology. 1(2):155-68 Summer 1979

Structure of the active site of prostaglandin synthase from studies of depsides: an alternate view. Prostaglandins, leukotrienes, and medicine. 13(2):139-42 Feb. 1984

Shortening of bleeding time by 1-deamino-8-D-arginine vasopressin in various bleeding disorders. Lancet. 1(8387):1145-89 May 26, 1984

The importance of international cooperation in science and technology. SRA Journal. 28(1/2):29(4 pgs) Summer/Fall 1996

Comparison of the effect of canola oil and sunflower oil on plasma lipids and lipoproteins and on in vivo thromboxane A2 and prostacyclin production in healthy young men. American Journal of Clinical Nutrition. 50(6):1382-8 Dec. 1989

Platelet protein phosphorylation. Advances in experimental medicine and biology. 192:235-48 1985

A hypothesis for a role for unsaturated fatty acids in electron transport and its potential application to understanding the mitochondrial respiratory chain. Medical Hypotheses. 6(5):491-9 May 1980

Fibrinogen is the receptor for the endogenous lectin of human platelets. Nature. 289(5799):688-90 Feb. 19, 1981

Platelet storage pool deficiency and prostaglandin synthesis in chronic granulocytic leukaemia. British Journal of Haematology. 40(4):597-607 Dec. 1978

Phosphatidic acid releases calcium from a platelet membrane fraction in vitro. Prostaglandins and Medicine. 1(5):387-96 Nov. 1978

Separable assembly of platelet pseudopodal and contractile cytoskeletons. Cell. 30(2):385-93 Sept. 1982

The chemiluminescence response of human platelets. Journal of Clinical Investigation. 61(3):807-14 Mar. 1978

Inhibition of platelet lipoxygenase by toluene-3,4-dithiol and other ferric iron chelators. Prostaglandins, leukotrienes, and medicine. 10(1):107-8 Jan. 1983

Biochemical studies of two patients with the gray platelet syndrome. Selective deficiency of platelet alpha granules. Journal of Clinical Investigation. 66(1):102-9 July 1980

Role of materials in an innovative economy. CIM Bulletin. Montreal: 88(995):92 Nov./Dec. 1995

Lysophosphatidic acid can activate platelets without increasing 32P-labelling of phosphatidic acid. Biochimica et biophysica acta.. 795(3):487-92 Oct. 4, 1984

Possible mechanisms of epinephrine actions in quin-2-loaded platelets refractory to arachidonic acid. Biochemical medicine and metabolic biology. 50(3):322-37 Dec. 1993

Phospholipid metabolism and cell stimulus activation coupling in platelets and other blood cells. Survey and synthesis of pathology research. 3(6):457-76 1984

Histamine as an intracellular messenger in human platelets. Advances in experimental medicine and biology. 344:209-19 1993

The bald eagle in Canada : proceedings of Bald Eagle Days, Winnipeg, August 18-20, 1983 / Jon M. Gerrard and Terrence M. Ingram, editors. Headingley, Man: White Horse Plains Publishers; vii, 272 p. c1985

Platelet storage pool deficiency, leukemia, and myelodysplastic syndromes. Leukemia & lymphoma. 8(4-5):277-81 Nov. 1992

Response of human bone marrow progenitor cells to X-rays in vitro. International journal of radiation biology. 54(4):593-600 Oct. 1988

Ultrastructural features of abnormal blood platelets. A review. American Journal of Pathology. 83(3):589-632 June 1976

Reduction of ferric heme to ferrous by lipid peroxides: possible relevance to the role of peroxide tone in the regulation of prostaglandin synthesis. Prostaglandins and Medicine. 4(2):73-8 Feb. 1980

Bleeding/bruising symptomatology in children with and without bleeding disorders. Thrombosis and Haemostasis. 65(3):237-41 Mar. 1991

Platelet-leukocyte interactions following arterial endothelial injury. American Journal of Pathology. 96(2):567-80 Aug. 1979

Alteration in the balance of prostaglandin and thromboxane synthesis in diabetic rats. Journal of Laboratory and Clinical Medicine. 95(6):950-8 June 1980

Prostaglandins as reducing agents: a model of adenylate cyclase activation?. Prostaglandins. 36(5):667-71 Nov. 1988

Platelet storage pool deficiency: diagnosis in patients with prolonged bleeding times and normal platelet aggregation. British Journal of Haematology. 75(1):118-21 May 1990

Effect of dietary alpha-linolenic acid and its ratio to linoleic acid on platelet and plasma fatty acids and thrombogenesis. Lipids. 28(9):811-7 Sept. 1993

Prostaglandin endoperoxides promote calcium release from a platelet membrane fraction in vitro. Prostaglandins and Medicine. 1(15):373-85 Nov. 1978

The role of iron in prostaglandin synthesis: ferrous iron mediated oxidation of arachidonic acid. Prostaglandins and Medicine. 1(1):55-70 July 1978

Long-term cultures of human peripheral blood lymphocytes with recombinant human interleukin-2 generate a population of virtually pure CD3+ CD16- CD56- large granular lymphocyte LAK cells. Clinical and experimental immunology. 82(2):416-21 Nov. 1990

Effects of nitroblue tetrazolium and vitamin E on platelet ultrastructure, aggregation, and secretion. American Journal of Pathology. 88(2):387-402 Aug. 1977

The platelet dense tubular system: its relationship to prostaglandin synthesis and calcium flux. Thrombosis and Haemostasis. 40(2):224-31 Oct. 31, 1978

Prostaglandins and leukotrienes: blood and vascular cell function. New York: M. Dekker; xii, 320 p. c1985

L-asparaginase-induced hypocomplementemia in acute lymphocytic leukemia (ALL) of childhood. American journal of pediatric hematology/oncology. 1(1):5-7 Spring 1979

Estimating closed population size and number of marked animals from sighting data. 55(4):716(15 pgs) Oct. 1991

Ultrastructure of clots during isometric contraction. Journal of Cell Biology. 93(3):775-87 June 1982

Histamine formed in stimulated human platelets is cytoplasmic. Biochemical and biophysical research communications. 164(1):164-8 Oct. 16, 1989

Inhibition of intravascular platelet aggregation by endothelium-derived relaxing factor: reversal by red blood cells. Blood. 76(5):953-8 Sept.1, 1990

Oral contraceptive use alters the balance of platelet prostaglandin and thromboxane synthesis. Prostaglandins and Medicine. 1(1):5-11 July 1978

Evidence that the peroxidase of the fatty acid cyclooxygenase acts via a Fenton type of reaction. Prostaglandins, leukotrienes, and medicine. 12(1):73-6 Sept. 1983

Activation of inositol cycle in large granular lymphocyte leukemia RNK following contact with an NK-sensitive tumor. Advances in prostaglandin, thromboxane, and leukotriene research. 17A:573-6 1987

Cyclic AMP and platelet prostaglandin synthesis. Prostaglandins. 14(1):39-50 July 1977

Vitamin E inhibits the release of calcium from a platelet fraction in vitro. Prostaglandins and Medicine. 2(3):203-16 Mar. 1979

Epinephrine and other activators of prostaglandin endoperoxide synthetase can reduce Fe3+-heme to Fe2+-heme. Prostaglandins and Medicine. 5(5):357-64 Nov. 1980

Battling for a better Manitoba: a history of the provincial Liberal Party. Winnipeg: Heartland Associates; 208 p. 2006

Plasminogen, plasminogen activator, and platelets in the regulation of clot lysis. Reconstitution and patient studies. Journal of laboratory and clinical Medicine. 100(6):986-96 Dec. 1982

Ferrous iron mediated oxidation of arachidonic acid: studies employing nitroblue tetrazolium (NBT). Prostaglandins and Medicine. 1 : 304-17 Oct. 1978

Inhibition of ferrous iron induced oxidation of arachidonic acid by indomethacin. Prostaglandins and Medicine. 2(2):97-108 Feb. 1979

Biology and management of bald eagles and ospreys : proceedings of 1st International Symposium on Bald Eagles and Ospreys, Montréal, 28-29 October, 1981 / David M. Bird, chief editor, Norman R. Seymour, Jon M. Gerrard, assistant editors. [Ste. Anne de Bellevue, Québec]: Macdonald Raptor Research Centre of McGill University : Raptor Research Foundation; x, 325 p. 1983

Labile aggregation stimulating substance, free fatty acids, and platelet aggregation. Journal of Laboratory and Clinical Medicine. 87(1):73-82 Jan. 1976

Proceedings: Effects of pH on arachidonic acid induced platelet aggregation. Thrombosis et diathesis haemorrhagica. 34(2):560 Nov. 15, 1975

Prostaglandins and otitis media: studies in the chinchilla. Otolaryngology and head and neck surgery. 88(3):316-23 May/June 1980

The influence of reserpine and ethylenediaminetetraacetic acid (EDTA) on serotonin storage organelles of blood platelets. American Journal of Pathology. 87(3):633-46 June 1977

Stimulation of platelet protein phosphorylation by arachidonic acid and endoperoxide analogs. Prostaglandins. 22(1):81-94 July 1981

Prostaglandins and thromboxanes: 'middlemen' modulating platelet function in hemostasis and thrombosis. Progress in hemostasis and thrombosis. 4:87-125 1978

Histamine is an intracellular messenger mediating platelet aggregation. Science. 243(4898):1596-9 Mar. 1989

Synthesis of intracellular histamine in platelets is associated with activation of protein kinase C, but not with mobilization of Ca2+. Biochemical journal. 273(Pt 2): 405-8 Jan. 15, 1991

Localization of platelet prostaglandin production in the platelet dense tubular system. American Journal of Pathology. 83(2):283-98 May 1976

Platelet aggregation and the influence of prostaglandins. Methods in enzymology. 86:642-54 1982

Differential effects of spermine on aggregation, inositol phosphate formation and protein phosphorylation in human platelets in response to thrombin, arachidonic acid and lysophosphatidic acid. Biochimica et biophysica acta. 883(2):247-52 Sept. 4, 1986

Interaction of arachidonic acid and heme iron in the synthesis of prostaglandins. Advances in prostaglandin and thromboxane research. 6:157-61 1980

Inherited platelet-storage pool deficiency associated with a high incidence of acute myeloid leukaemia. British journal of haematology. 79(2):246-55 Oct. 1991

Effects of the lonophore A23187 on blood platelets I. Influence on aggregation and secretion. American Journal of Pathology. 77(2):135-49 Nov. 1974

Granulophysin is located in the membrane of azurophilic granules in human neutrophils and mobilizes to the plasma membrane following cell stimulation. American Journal of Pathology. 144(6):1369-80 June 1994

Oncornavirus-like particles from cultured bone marrow cells preceding leukemia and malignant histiocytosis. Proceedings of the National Academy of Sciences of the United States of America. 72(7):2804-8 July 1975

A hypothesis for the mechanism of superoxide production by phagocytic cells. Medical Hypotheses. 7(11):1389-95 Nov. 1981

Fibroblasts require protein kinase C activation to respond to hyaluronan with increased locomotion. Matrix biology. 20(3):183-92 June 2001

The ultrastructure of defective human platelets. Molecular and cellular biochemistry. 21(2):109-28 Nov. 1, 1978

The interactive effects of Type A behavior and hostility on bleeding time thromboxane and prostacyclin formation. Journal of psychosomatic research. 35(6):645-50 1991

Inhibition of prostaglandin (PG) synthesis in sheep vesicular gland microsomes (SVGM) by nitroblue tetrazolium (NBT) and vitamin E (VE). Prostaglandins and Medicine. 2(2):111-21 Feb. 1979

alpha-Actinin deficiency in thrombasthenia: possible identity of alpha-actinin and glycoprotein III. American Journal of Pathology. 94(3):509-28 Mar. 1979

Smoking and platelet labile aggregation stimulating substance (LASS) synthesizing activity. Thrombosis Research. 9(6):661-8 Dec. 1976

Evidence for two mechanisms of thrombin-induced platelet activation: one proteolytic, one receptor mediated. Biochemistry and cell biology. 67(7):332-6 July 1989

Measurements of 6-keto-prostaglandin F1 alpha and thromboxane B2 in bleeding time blood: relation to bleeding and vascular disorders?. Canadian journal of physiology and pharmacology. 67(8):922-8 Aug. 1989

Proceedings: Differences in platelet storage pool deficiency (SPD) of Hermansky Pudlak syndrome (HPS) and non-albinos (NA). Thrombosis et diathesis haemorrhagica. 34(1):360-1 Sept.30, 1975

Biphasic modulation of platelet phospholipase A2 activity and platelet aggregation by mepacrine (quinacrine). Biochimica et biophysica acta. 713(1):170-2 Oct. 14, 1982

Platelet ultrastructure in relation to platelet function. Progress in clinical and biological research. 28:5-23 1978

The influence of vitamin E quinone on platelet structure, function, and biochemistry. Blood. 55(6):907-14 June 1980

Interaction of microtubules and microfilaments in platelet contractile physiology. Methods and achievements in experimental pathology. 9 : 1-39 1979

Histamine as an intracellular messenger. Biochemical pharmacology. 40(8):1677-81 Oct. 1990

The role of phosphorylation/dephosphorylation reactions in the function of blood platelets. Agents and actions. Supplements. 20:129-45 1986

Protein kinase C, membrane fusion and platelet granule secretion. Biochemical Society transactions. 21(2):289-93 May 1993

Increased phosphatidic acid and decreased lysophosphatidic acid in response to thrombin is associated with inhibition of platelet aggregation. Biochemistry and cell biology. 71(9-10):432-9 Sept./Oct. 1993

Effect of cholesterol on production of thromboxane b2 by platelets in vitro. New England Journal of Medicine. 302(1):6-10 Jan. 3, 1980

Lysophosphatidic acids. II. Interaction of the effects of adenosine diphosphate and lysophosphatidic acids in dog, rabbit, and human platelets. American Journal of Pathology. 97(3):531-47 Dec. 1979

Salicylic acid inhibition of the irreversible effect of acetylsalicyclic aicd on prostaglandin synthetase may be due to competition for the enzyme cationic binding site. Prostaglandins and Medicine. 6(2):161-4 Feb. 1981

The endogenous lectin of human platelets is an alpha-granule component. Blood. 58(1):153-7 July 1981

Free radicals in health and disease. Molecular and cellular biochemistry. 84(2):121-2 Dec. 1988

The structured interview elicits a differential prostacyclin response in A and B behaviour types. Canadian Journal of Cardiology. 7(4):170-4 May 1991

Synthesis and biological evaluation of 9,11-azo-13-oxa-15-hydroxyprostanoic acid, a potent inhibitor of platelet aggregation. Journal of medicinal chemistry. 22(11):1402-8 Nov. 1979

Effects of the lonophore A23187 on the blood platelets II. Influence on ultrastructure. American Journal of Pathology. 77(2):151-66 Nov. 1974

Wide distribution of granulophysin epitopes in granules of human tissues. Laboratory investigation. 68(5):509-19 May 1993

A hypothesis for the interaction of heme and arachidonic acid in the synthesis of prostaglandins. Medical Hypotheses. 5(6):683-93 June 1979

1-arachidonyl-monoglyceride causes platelet aggregation: indirect evidence for an acylglycerol acylhydrolase involvement in the release of arachidonic acid for prostaglandin synthesis. Prostaglandins and Medicine. 4(6):419-30 June 1980

Long-term science and technology policy key to sustainable economic growth. Canadian Chemical News. 46(8):26 Sept. 1994

Mepacrine (quinacrine) inhibition of thrombin-induced platelet responses can be overcome by lysophosphatidic acid. Biochimica et biophysica acta. 842(2-3):189-94 Oct. 17, 1985

Fatty acid composition of umbilical arteries and veins: possible implications for the fetal EFA-status. Lipids. 24(6):511-7 June 1989

Lysophosphatidic acids: III. Enhancement of neutrophil chemotaxis. American journal of pathology. 100(3):609-18 Sept. 1980

Identification of prostaglandins and other arachidonic acid metabolites in experimental otitis media. Prostaglandins, leukotrienes, and medicine. 8(3):249-61 Mar. 1982

An immunoenzyme histochemical technique for the detection of platelet antibodies from the serum of patients with idiopathic (autoimmune) thrombocytopenic purpura (ITP). British Journal of Haematology. 37(2):265-75 Oct. 1977

Growth-promoting activity of desmopressin in murine leukemia cells treated in vitro. Cancer Research. 48(24 Pt 1):7055-9 Dec. 1988

Arachidonic acid metabolism in nasal polyps and allergic inflammation. Minnesota medicine. 64(10):605-10 Oct. 1981

Hyperactivity of neutrophil leukotactic responses during active bacterial infection. Journal of Clinical Investigation. 53(4):996-1002 Apr. 1974

A reassessment of the bleeding time: association of age, hematocrit, platelet function, von Willebrand factor, and bleeding time thromboxane B2 with the length of the bleeding time. Clinical and investigative medicine. 12(3):165-71 June 1989

Arachidonic acid peroxidation, prostaglandin synthesis and platelet function. Photochemistry and photobiology. 28(4-5):845-50 Oct./Nov. 1978

Recent advances in platelet structural physiology. Supplementum... ad Thrombosis and haemostasis. 63:49-60 1978

The influence of aspirin and indomethacin on the platelet contractile wave. American Journal of Pathology. 82(3):513-26 Mar. 1976

Factors influencing bald eagle densities in North Central Saskatchewan. Journal of Wildlife Management. 57(4):771 (8 pgs) Oct. 1993

Production of inositol-phospholipid-derived second messengers in a rat natural killer cell line exposed to susceptible tumor targets. Natural immunity and cell growth regulation. 8(4):223-30 1989

Identification of a platelet dense granule membrane protein that is deficient in a patient with the Hermansky-Pudlak syndrome. Blood. 77(1):101-12 Jan.1, 1991

Post-receptor events associated with thrombin-induced platelet activation. Blood coagulation & fibrinolysis. 4(6):975-91 Dec. 1993

Contractile activity of neonatal platelets. Pediatric research. 21(3):293-5 Mar. 1987

Characterization of the gastroprotective effects of N,N-diethyl-2-[4-(phenylmethyl)phenoxy]-ethanamine hydrochloride, a non-H1/non-H2 histamine antagonist. Digestion. 47(3):143-8 1990

Reduction of a disulfide bond by beta-adrenergic agonists: evidence in support of a general. Medical Hypotheses. 22(1):45-9 Jan. 1987

A role for prostacyclin in bruising symptomatology. Pediatrics. 90(1 Pt 1):33-6 July 1992

Enhanced electron transfer by GTP: cross-membrane electron signaling by G-proteins?. Free radical biology & medicine. 11(2):187-90 1991

Reduction of a metal or disulfide bond associated with the receptor: a general hypothesis for the mechanism of action of adrenergic agents. Medical Hypotheses. 22(1):35-44 Jan. 1987

Evaluation of the careers of graduates of the University of Manitoba's BSc (Medicine) program. Canadian Medical Association Journal. 139(11):1063-8 Dec. 1, 1988

Platelets from bleeding Simmental cattle mobilize calcium, phosphorylate myosin light chain and bind normal numbers of fibrinogen molecules but have abnormal cytoskeletal assembly and aggregation in response to ADP. Thrombosis and haemostasis. 71(2):240-6 Feb. 1994

Phosphorylation of platelet actin-binding protein during platelet activation. Blood. 59(3):466-71 Mar. 1982

The effect of regular and enteric-coated aspirin on bleeding time, thromboxane, and prostacyclin. Prostaglandins, leukotrienes, and essential fatty acids. 49(1):515-20 July 1993

The inhibition of platelet aggregation of metastatic H-ras-transformed 10T1/2 fibroblasts with castanospermine, an N-linked glycoprotein processing inhibitor. Cancer letters. 60(3):185-91 Dec.1, 1991

Child health research in Manitoba. Headingley, Man.: White Horse Plains Publishers; viii, 120 p. 1993

The young investigator in Canada. Clinical and investigative medicine. 15(3):255-6 June 1992

Studies in patients with bleeding disorders show that platelet-vessel interaction is important for thromboxane formation in bleeding time wounds. Thrombosis research. 60(1):79-85 Oct. 1990

Effects of 2,2'-dipyridyl and related compounds on platelet prostaglandin synthesis and platelet function. Biochimica et biophysica acta. 628(4):468-79 Apr. 3, 1980

Allopurinol can act as an electron transfer agent. Is this relevant during reperfusion injury?. Biochemical and biophysical research communications. 137(1):76-9 May 29, 1986

The bald eagle: haunts and habits of a wilderness monarch. Washington: Smithsonian Institution Press; xiv, 177 p. 1988

Halothane stimulates the aggregation of platelets of both normal individuals and those susceptible to malignant hyperthermia. British Journal of Anaesthesia. 55(12):1249-57 Dec. 1983

Sharing of antigenic epitopes between synaptophysin and granulophysin. Journal of cellular biochemistry. 49(1):59-65 May 1992

The influence of lysophosphatidic acid on platelet protein phosphorylation. Biochemistry and cell biology. 65(7):642-50 July 1987

An enzyme-linked immunosorbent assay for 6-keto PGF1 alpha. Prostaglandins. 31(3):375-83 Mar. 1986

A penicillin-resistant pneumococcus. Journal of pediatrics. 93(4):624-6 Oct. 1978

Platelet aggregation: cellular regulation and physiologic role. Hospital practice (Office ed.). 23 (1):89-98ff. Jan. 15, 1988

Reduction of heme by lipid peroxides and its potential relevance to understanding control of cyclo-oxygenase activity. Progress in lipid research.. 20:299-301 1981

Evaluation of the careers of graduates of the University of Manitoba's BSc (Medicine) program. Canadian Medical Association Journal. 139:1063-68 Dec. 1, 1988

The structure and function of platelets, with emphasis on their contractile nature. Pathobiology annual. 6:31-59 1976

Biochemical and ultrastructural studies suggest that the effects of thapsigargin on human platelets are mediated by changes in intracellular calcium but not by intracellular histamine. Thrombosis and haemostasis. 68(6):714-8 Dec. 7, 1992

Plasma phospholipid fatty acids in the Central Canadian arctic: biocultural explanations for ethnic differences. American journal of physical anthropology. 109(1):9-18 May 1999

Protein phosphorylation and platelet secretion. Nouvelle revue francaise d'hematologie. 27(4):267-73 1985

Leukophysin: a 28-kDa granule membrane protein of leukocytes. Journal of Immunology. 147(9):3053-9 Nov.1, 1991

Phosphorylation of tyrosine enhances its electron transfer capability: a model of redox modulation as oncogene expression?. Medical Hypotheses. 26(4):271-3 Aug. 1988

In vivo measurement of thromboxane B2 and 6-keto-prostaglandin F1 alpha in humans in response to a standardized vascular injury and the influence of aspirin. Circulation. 79(1):29-38 Jan. 1989

Wiskott-Aldrich syndrome: detection of carrier state by metabolic stress of platelets. Lancet. 1(8056):121-3 Jan. 21, 1978

Aerobic fitness level (VO2max) moderates the increased cardiovascular function and basal thromboxane formation of young healthy Type A males. Behavioral medicine. 18(1):33-9 Spring 1992